SINGLE-CELL HETEROGENEITY AND DYNAMIC EVOLUTION OF PH-LIKE ACUTE LYMPHOBLASTIC LEUKEMIA PATIENT WITH NOVEL TPR-PDGFRB FUSION GENE

Single-cell heterogeneity and dynamic evolution of Ph-like acute lymphoblastic leukemia patient with novel TPR-PDGFRB fusion gene

Abstract Philadelphia chromosome-like Direction label acute lymphoblastic leukemia (Ph-like ALL) is a refractory and recurrent subtype of B-cell ALL enriched with kinase-activating rearrangements.Incomplete understanding of the heterogeneity within the tumor cells presents a major challenge for the diagnosis and therapy of Ph-like ALL.Here, we exhi

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Review of 4Pi Fluorescence Nanoscopy

Since the 1990s, continuous technical and scientific advances have defied the diffraction limit in microscopy and enabled three-dimensional (3D) super-resolution Chalkboards imaging.An important milestone in this pursuit is the coherent utilization of two opposing objectives (4Pi geometry) and its combination with super-resolution microscopy.Herein

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